EPCAM-DT

Across TCGA pan-cancer cohorts, EPCAM-DT RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated EPCAM-DT data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EPCAM-DT RNA is associated with better overall survival. In most high-consensus cancer types, elevated EPCAM-DT expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and KIRP are the cancer types where EPCAM-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.582	0.287	<.001	65	view →
BLCA	OS	Median	All	0.585	0.323	<.001	54	view →
KIRP	OS	Tertile	II,III,IV	0.926	0.702	.007	54	view →
ACC	DFS	Median	All	0.222	0.652	<.001	54	view →
LGG	OS	Median	All	0.881	0.736	<.001	49	view →
KIRC	OS	Tertile	All	0.832	0.739	.003	39	view →
PAAD	DFS	Median	All	0.498	0.261	.004	31	view →
STAD	DFS	Median	IV	0.137	0.500	.007	29	view →
THYM	OS	Median	II,III,IV	0.885	1.000	.009	15	view →
UCS	DFS	Tertile	II,III,IV	0.568	0.204	.023	10	view →
LUAD	DFS	Quartile	All	0.857	0.690	.017	9	view →
DLBC	OS	Median	III,IV	0.272	1.000	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

EPCAM-DT–HNSC (OS)

Open the HNSC breakdown →