EPCAM-DT

Across TCGA pan-cancer cohorts, EPCAM-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of EPCAM-DT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EPCAM-DT RNA is repressed in tumor relative to normal tissue. In most cancer types EPCAM-DT is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and READ are the cancer types where EPCAM-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPCAM-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.520	<.001	12	view →
KICH	Male	All	−0.498	<.001	10	view →
READ	Male	All	−2.130	<.001	7	view →
LUSC	Male	III,IV	−0.510	<.001	7	view →
BRCA	Female	All	−0.263	<.001	6	view →
LIHC	All	All	+0.103	<.001	6	view →
THCA	Male	III,IV	−0.497	.001	5	view →
UCEC	All	All	−0.470	.001	4	view →
CHOL	Male	All	+0.420	<.001	4	view →
HNSC	All	All	−0.075	.013	4	view →
PAAD	Female	All	+0.609	.049	2	view →
KIRC	All	All	+0.118	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

EPCAM-DT–COAD

Open the COAD breakdown →