EPC2

Across TCGA cell cohorts, EPC2 mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPC2-associated genes across cancer lineages are XAGE5, PRAMEF19, and C6orf118. Each is linked with EPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPC2-to-partner and partner-to-EPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by EPC2-low versus EPC2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPC2→partner) and Y-score (partner→EPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	XAGE5 →	+0.534	+4.643	<.001	.005	3	2
BREAST	PRAMEF19 →	+0.019	+5.169	<.001	.005	3	2
BLOOD_Myeloma	C6orf118 →	+0.113	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	F9 →	+0.035	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	NEUROD4 →	+0.156	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	PLCZ1 →	+0.127	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

XAGE5 by EPC2 expression — BLOOD_Lymphoma

Explore this box plot interactively →