EPC2

Across TCGA pan-cancer cohorts, EPC2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated EPC2 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EPC2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated EPC2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, ACC, and HNSC are the cancer types where EPC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.720	0.547	<.001	113	view →
ACC	DFS	Median	All	0.192	0.695	<.001	71	view →
HNSC	DFS	Tertile	All	0.771	0.625	.003	59	view →
KIRP	DFS	Quartile	II,III,IV	0.261	0.759	<.001	58	view →
BRCA	OS	Median	III,IV	0.631	0.336	.003	31	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
GBM	DFS	Median	All	0.420	0.176	<.001	20	view →
SCLC	DFS	Tertile	II,III,IV	0.755	0.415	.014	17	view →
UVM	DFS	Quartile	III,IV	0.183	0.706	.012	15	view →
UCS	OS	Median	III,IV	0.719	0.430	.028	14	view →
CHOL	DFS	Median	All	0.726	0.227	.019	12	view →
SKCM	OS	Quartile	IV	0.856	0.488	.014	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

EPC2–KIRC (OS)

Open the KIRC breakdown →