EPB41L4B

Across TCGA pan-cancer cohorts, EPB41L4B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated EPB41L4B data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EPB41L4B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EPB41L4B expression acts as an unfavorable survival marker, although some lineages such as SCLC and STAD show a favorable association.

KIRC, KIRP, and BRCA are the cancer types where EPB41L4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.553	0.702	<.001	136	view →
KIRP	DFS	Median	All	0.783	0.916	<.001	105	view →
BRCA	OS	Median	II,III,IV	0.493	0.647	<.001	77	view →
ACC	DFS	Quartile	All	0.544	0.900	<.001	49	view →
ESCA	DFS	Median	All	0.406	0.880	.003	27	view →
SKCM	OS	Tertile	II,III,IV	0.290	0.505	.006	19	view →
SCLC	DFS	Median	All	0.404	0.185	.011	14	view →
PCPG	DFS	Quartile	All	0.667	1.000	.015	11	view →
UVM	DFS	Median	III,IV	0.382	0.682	.016	7	view →
STAD	DFS	Tertile	All	0.724	0.603	.022	6	view →
PAAD	DFS	Median	III,IV	0.370	0.853	.010	6	view →
LUSC	DFS	Tertile	All	0.811	0.729	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

EPB41L4B–KIRC (OS)

Open the KIRC breakdown →