EPB41L4B

Across TCGA pan-cancer cohorts, EPB41L4B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of EPB41L4B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EPB41L4B RNA is repressed in tumor relative to normal tissue. In most cancer types EPB41L4B is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where EPB41L4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPB41L4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.024	<.001	12	view →
COAD	Female	II,III,IV	−1.562	<.001	12	view →
HNSC	Male	IV	+2.020	<.001	11	view →
THCA	Female	II,III,IV	−1.339	<.001	11	view →
BLCA	All	III,IV	+1.690	<.001	10	view →
KIRP	Male	All	−2.191	<.001	7	view →
BRCA	All	II,III,IV	−0.873	<.001	6	view →
CHOL	All	All	−2.156	<.001	5	view →
LIHC	Female	All	−1.642	<.001	5	view →
STAD	All	All	+1.020	.005	4	view →
READ	All	All	−0.978	.002	4	view →
LUAD	All	IV	+1.660	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

EPB41L4B–KIRC

Open the KIRC breakdown →