EPB41L4B

Across TCGA pan-cancer cohorts, EPB41L4B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EPB41L4B data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher EPB41L4B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EPB41L4B expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

LSCC, PDAC, and COAD are the cancer types where EPB41L4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.846	0.546	.014	14	view →
PDAC	DFS	Tertile	All	0.235	0.437	.011	14	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.920	.040	12	view →
HNSC	DFS	Tertile	All	0.317	0.860	.024	12	view →
LUAD	DFS	Quartile	All	0.478	1.000	.007	8	view →
CCRCC	OS	Median	All	0.657	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EPB41L4B–LSCC (DFS)

Open the LSCC breakdown →