EPB41L4A

Across TCGA patient cohorts, EPB41L4A mutation is significantly associated with the RNA expression of many other genes, with 4,129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPB41L4A-associated genes across cancer lineages are GLRX5, ANKRD39, and UQCRC1. Each is linked with EPB41L4A in more than 3 cancer types. Because this analysis shows association rather than direction, both EPB41L4A-to-partner and partner-to-EPB41L4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRX5 grouped by EPB41L4A-low versus EPB41L4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L4A→partner) and Y-score (partner→EPB41L4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLRX5 →	+0.272	+2.169	.009	<.001	3	4
UCEC	ANKRD39 →	+0.217	+3.606	.007	.001	3	4
UCEC	UQCRC1 →	+0.318	+2.114	.003	<.001	3	4
KIRP	ATF4P1 →	+0.044	+4.497	<.001	.009	3	3
COAD	GMDS →	+0.495	+3.489	.007	.002	3	3
COAD	BNIP3L →	+0.935	+2.820	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,129 associations by consensus.

GLRX5 by EPB41L4A expression — UCEC

Explore this box plot interactively →