EPB41L4A-DT

Across TCGA pan-cancer cohorts, EPB41L4A-DT RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated EPB41L4A-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EPB41L4A-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated EPB41L4A-DT expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

KIRC, KIRP, and HNSC are the cancer types where EPB41L4A-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.753	0.501	<.001	161	view →
KIRP	OS	Tertile	All	0.883	0.563	<.001	103	view →
HNSC	DFS	Quartile	All	0.713	0.488	<.001	98	view →
MESO	OS	Quartile	All	0.775	0.381	<.001	80	view →
LUAD	OS	Quartile	II,III,IV	0.964	0.626	<.001	51	view →
KICH	OS	Median	III,IV	1.000	0.733	.001	49	view →
LGG	OS	Median	All	0.723	0.901	<.001	48	view →
THCA	DFS	Median	All	0.902	0.754	<.001	44	view →
OV	DFS	Median	III,IV	0.328	0.408	.010	36	view →
LIHC	OS	Tertile	All	0.848	0.606	.001	35	view →
CHOL	OS	Median	II,III,IV	0.915	0.413	.006	28	view →
ACC	DFS	Tertile	II,III,IV	0.659	0.283	.019	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

EPB41L4A-DT–KIRC (DFS)

Open the KIRC breakdown →