EPB41L4A-DT

Across TCGA pan-cancer cohorts, EPB41L4A-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of EPB41L4A-DT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EPB41L4A-DT RNA is repressed in tumor relative to normal tissue. In most cancer types EPB41L4A-DT is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where EPB41L4A-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPB41L4A-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−0.856	<.001	12	view →
LUAD	Female	III,IV	−1.158	<.001	9	view →
COAD	Female	All	−0.842	<.001	9	view →
LUSC	Male	II,III,IV	−1.101	<.001	8	view →
THCA	Male	II,III,IV	−0.480	.003	5	view →
CHOL	All	All	+1.322	<.001	3	view →
READ	Female	All	−1.170	<.001	3	view →
KICH	Male	All	−0.844	.036	2	view →
KIRC	Female	All	+0.537	.001	2	view →
LIHC	Male	All	−0.340	<.001	2	view →
PRAD	All	All	−0.278	.028	2	view →
BRCA	All	All	−0.169	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

EPB41L4A-DT–HNSC

Open the HNSC breakdown →