EPB41L3

Across TCGA patient cohorts, EPB41L3 mutation is significantly associated with the RNA expression of many other genes, with 6,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPB41L3-associated genes across cancer lineages are LDHA, PTP4A3, and UTP18. Each is linked with EPB41L3 in more than 4 cancer types. Because this analysis shows association rather than direction, both EPB41L3-to-partner and partner-to-EPB41L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LDHA grouped by EPB41L3-low versus EPB41L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L3→partner) and Y-score (partner→EPB41L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LDHA →	+0.476	+1.807	<.001	<.001	3	5
COAD	PTP4A3 →	-0.862	-3.989	.001	<.001	3	5
UCEC	UTP18 →	+0.385	+1.378	.001	<.001	3	4
COAD	PLA2G4A →	+1.054	+2.087	.003	.005	3	4
UCEC	CYYR1 →	-0.405	-1.530	.004	.003	3	4
COAD	TLCD3A →	+0.562	+2.916	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,928 associations by consensus.

LDHA by EPB41L3 expression — UCEC

Explore this box plot interactively →