EPB41L3

Across TCGA pan-cancer cohorts, EPB41L3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EPB41L3 data layer compared with 10 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EPB41L3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated EPB41L3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, PAAD, and STAD are the cancer types where EPB41L3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.519	0.209	.001	39	view →
PAAD	DFS	Tertile	All	0.433	0.228	.003	38	view →
STAD	OS	Tertile	III,IV	0.351	0.701	.004	33	view →
LUSC	OS	Median	All	0.383	0.621	.001	31	view →
UCS	DFS	Median	II,III,IV	0.453	0.137	.002	28	view →
CHOL	DFS	Quartile	All	0.839	0.147	.001	21	view →
BRCA	OS	Median	III,IV	0.896	0.763	.002	19	view →
THCA	OS	Median	III,IV	0.945	1.000	.005	18	view →
DLBC	DFS	Tertile	III,IV	0.074	0.984	.017	18	view →
KIRC	DFS	Median	All	0.714	0.527	.009	16	view →
LUAD	OS	Median	II,III,IV	0.621	0.344	.005	15	view →
SCLC	DFS	Tertile	II,III,IV	0.813	0.498	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EPB41L3–HNSC (DFS)

Open the HNSC breakdown →