EPB41L3

Across TCGA patient cohorts, EPB41L3 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPB41L3-associated genes across cancer lineages are FoxM1, Annexin-1, and mTOR_pS2448. Each is linked with EPB41L3 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPB41L3-to-partner and partner-to-EPB41L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by EPB41L3-low versus EPB41L3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L3→partner) and Y-score (partner→EPB41L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FoxM1 →	+0.343	+2.502	<.001	.001	3	4
UCEC	Annexin-1 →	+0.489	+2.756	<.001	<.001	3	4
LUAD	mTOR_pS2448 →	-0.220	-3.000	.035	.036	2	4
STAD	JNK_pT183_Y185 →	-0.112	-2.906	.006	.001	3	3
STAD	p62 Lck ligand →	+0.315	+1.999	.015	.009	3	3
STAD	Bap1-c-4 →	+0.406	+2.906	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

FoxM1 by EPB41L3 expression — STAD

Explore this box plot interactively →