EPB41

Across TCGA cell cohorts, EPB41 mutation is significantly associated with the RNA expression of many other genes, with 720 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPB41-associated genes across cancer lineages are FBXW10, SEC14L3, and OR14I1. Each is linked with EPB41 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPB41-to-partner and partner-to-EPB41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by EPB41-low versus EPB41-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41→partner) and Y-score (partner→EPB41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.163	+2.714	.008	.004	3	2
SKIN	SEC14L3 →	+0.009	+4.562	<.001	<.001	3	1
SKIN	OR14I1 →	+0.105	+3.807	<.001	.007	3	1
SKIN	OR10G2 →	+0.014	+4.437	<.001	.004	3	1
BREAST	GFRA4 →	+0.022	+4.754	<.001	<.001	3	1
BREAST	CRYBA4 →	+0.086	+3.691	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 720 associations by consensus.

FBXW10 by EPB41 expression — LARGE_INTESTINE

Explore this box plot interactively →