EPAS1

Across TCGA cell cohorts, EPAS1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPAS1-associated genes across cancer lineages are PVALEF, AVP, and ZAN. Each is linked with EPAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPAS1-to-partner and partner-to-EPAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PVALEF grouped by EPAS1-low versus EPAS1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPAS1→partner) and Y-score (partner→EPAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PVALEF →	+0.070	+3.754	<.001	.002	3	2
SOFT_TISSUE	AVP →	+0.130	+5.977	<.001	.001	3	1
SOFT_TISSUE	ZAN →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
LARGE_INTESTINE	C9orf153 →	+0.151	+3.497	<.001	.004	3	1
LARGE_INTESTINE	TEX46 →	+0.118	+3.497	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PVALEF by EPAS1 expression — SKIN

Explore this box plot interactively →