Across TCGA patient cohorts, EP400 protein abundance is significantly associated with the RNA expression of many other genes, with 13,252 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EP400-associated genes across cancer lineages are USP21, CHTOP, and C2orf68. Each is linked with EP400 in more than 5 cancer types. Because this analysis shows association rather than direction, both EP400-to-partner and partner-to-EP400 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EP400→partner) and Y-score (partner→EP400) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP21 →	+0.472	+0.197	<.001	<.001	3	6
HNSC	CHTOP →	+0.458	+0.231	.001	<.001	3	6
LSCC	C2orf68 →	+0.486	+0.196	<.001	<.001	3	6
OV	ZBTB12 →	+0.827	+0.165	.001	.002	3	6
HNSC	CNNM3-DT →	+0.767	+0.143	<.001	<.001	3	6
OV	FAP →	-1.544	-0.142	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,252 associations by consensus.

Exploration

EP400 survival (RNA) · tumor vs normal (RNA) · all EP400 data types