Across TCGA patient cohorts, EP400 mutation is significantly associated with the RNA expression of many other genes, with 8,612 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EP400-associated genes across cancer lineages are YWHAE, EIF4E, and C1orf174. Each is linked with EP400 in more than 5 cancer types. Because this analysis shows association rather than direction, both EP400-to-partner and partner-to-EP400 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EP400→partner) and Y-score (partner→EP400) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	YWHAE →	+0.491	+2.502	<.001	.001	3	6
BRCA	EIF4E →	+0.460	+3.348	.005	.005	3	5
STAD	C1orf174 →	+0.414	+2.716	<.001	.002	3	5
COAD	PTMAP4 →	+1.382	+2.026	<.001	<.001	3	5
STAD	PRKCZ →	+0.569	+2.569	<.001	<.001	3	5
STAD	MRPS27 →	+0.542	+3.492	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,612 associations by consensus.

Exploration

EP400 survival (RNA) · tumor vs normal (RNA) · all EP400 data types