EP300

Across TCGA patient cohorts, EP300 protein abundance is significantly associated with the RNA expression of many other genes, with 17,243 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EP300-associated genes across cancer lineages are ZBED4, ADSL, and SNRPD3. Each is linked with EP300 in more than 6 cancer types. Because this analysis shows association rather than direction, both EP300-to-partner and partner-to-EP300 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EP300 versus ZBED4 in HNSC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EP300→partner) and Y-score (partner→EP300) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZBED4 →	+0.434	+0.186	<.001	<.001	3	7
GBM	ADSL →	+0.397	+0.246	<.001	<.001	3	7
HNSC	SNRPD3 →	+0.666	+0.182	<.001	<.001	3	6
BRCA	HMGXB4 →	+0.623	+0.233	<.001	<.001	3	6
HNSC	TOMM22 →	+0.769	+0.198	.003	<.001	3	5
HNSC	MIEF1 →	+0.476	+0.209	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,243 associations by consensus.

EP300 vs ZBED4 — HNSC

Explore this scatter interactively →