EP300

Across TCGA pan-cancer cohorts, EP300 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of EP300’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EP300 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EP300 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where EP300 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EP300 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.750	<.001	8	view →
LIHC	All	All	+0.573	<.001	6	view →
THCA	All	All	−0.498	<.001	6	view →
CHOL	Male	All	+1.840	<.001	5	view →
STAD	All	II,III,IV	+0.649	.003	5	view →
PRAD	All	All	+0.322	.019	2	view →
ESCA	Female	All	+0.903	.014	1	view →
COAD	Female	IV	−0.419	.008	1	view →
LUSC	All	All	+0.313	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

EP300–HNSC

Open the HNSC breakdown →