EP300

Across TCGA patient cohorts, EP300 mutation is significantly associated with the RNA expression of many other genes, with 5,313 significant associations in total. COAD shows the largest number of these associations.

The most reproducible EP300-associated genes across cancer lineages are CXCL9, SRP19, and CXCL10. Each is linked with EP300 in more than 4 cancer types. Because this analysis shows association rather than direction, both EP300-to-partner and partner-to-EP300 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXCL9 grouped by EP300-low versus EP300-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EP300→partner) and Y-score (partner→EP300) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCL9 →	+2.096	+2.947	<.001	<.001	3	5
COAD	SRP19 →	+0.439	+2.652	.002	.004	3	5
COAD	CXCL10 →	+1.754	+3.489	<.001	.002	3	5
CESC	POLDIP3 →	+0.283	+1.925	.008	.003	3	5
HNSC	MRPL39 →	+0.289	+1.830	.007	.002	3	5
COAD	C3orf62 →	+0.255	+3.348	.009	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,313 associations by consensus.

CXCL9 by EP300 expression — UCEC

Explore this box plot interactively →