EP300

Across TCGA cell cohorts, EP300 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,742 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EP300-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Negative regulation of chromosome condensation, and Positive regulation of T-helper 17 cell lineage commitment. Each is linked with EP300 in more than 19 cancer types. Because this analysis shows association rather than direction, both EP300-to-partner and partner-to-EP300 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by EP300-low versus EP300-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EP300→partner) and Y-score (partner→EP300) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of gene expression, epigenetic →	+0.113	+1.166	<.001	<.001	3	20
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.176	+1.323	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Positive regulation of T-helper 17 cell lineage commitment →	+0.225	+1.210	<.001	<.001	3	19
BONE	Epigenetic regulation of gene expression →	+0.109	+1.093	<.001	<.001	3	19
OESOPHAGUS	Positive regulation of cell fate commitment →	+0.237	+0.826	<.001	.007	3	19
LUNG_NSCLC_LUSC	Negative regulation of brown fat cell differentiation →	+0.265	+1.294	.002	.003	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,742 associations by consensus.

Negative regulation of gene expression, epigenetic by EP300 expression — BONE

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