EP300

Across TCGA cell cohorts, EP300 mutation is significantly associated with the RNA expression of many other genes, with 1,527 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EP300-associated genes across cancer lineages are ZNF286A, TIPIN, and ZNF184. Each is linked with EP300 in more than 4 cancer types. Because this analysis shows association rather than direction, both EP300-to-partner and partner-to-EP300 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF286A grouped by EP300-low versus EP300-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EP300→partner) and Y-score (partner→EP300) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF286A →	+1.365	+3.518	<.001	<.001	3	5
LARGE_INTESTINE	TIPIN →	+0.460	+1.721	.004	.003	3	4
BLOOD_Leukemia	ZNF184 →	+0.628	+2.614	.007	.003	3	3
BLOOD_Lymphoma	ACYP1 →	+0.670	+2.700	.001	.003	3	3
BLOOD_Lymphoma	EFCAB7 →	+0.442	+2.700	.009	.003	3	3
LARGE_INTESTINE	SLC25A17 →	+0.587	+3.321	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,527 associations by consensus.

ZNF286A by EP300 expression — BLOOD_Leukemia

Explore this box plot interactively →