ENTPD3

Across TCGA patient cohorts, ENTPD3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENTPD3-associated genes across cancer lineages are Src_pY416, MEK1, and Caspase-8. Each is linked with ENTPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENTPD3-to-partner and partner-to-ENTPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by ENTPD3-low versus ENTPD3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENTPD3→partner) and Y-score (partner→ENTPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src_pY416 →	+0.351	+2.000	.010	.031	3	2
UCEC	MEK1 →	+0.284	+2.700	.047	.006	3	2
UCEC	Caspase-8 →	-0.277	-3.780	.004	<.001	3	2
SKCM	ETS-1 →	-0.256	-2.700	.039	.006	3	1
SKCM	PRDX1 →	-0.281	-2.000	.032	.031	3	1
UCEC	14-3-3_beta →	-0.112	-3.558	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Src_pY416 by ENTPD3 expression — SKCM

Explore this box plot interactively →