ENSA

Across TCGA patient cohorts, ENSA protein abundance is significantly associated with the RNA expression of many other genes, with 7,362 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ENSA-associated genes across cancer lineages are GOLPH3L, PRUNE1, and HAX1. Each is linked with ENSA in more than 6 cancer types. Because this analysis shows association rather than direction, both ENSA-to-partner and partner-to-ENSA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ENSA versus GOLPH3L in BRCA, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENSA→partner) and Y-score (partner→ENSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GOLPH3L →	+0.722	+0.394	<.001	<.001	3	7
LSCC	PRUNE1 →	+0.637	+0.322	<.001	<.001	3	7
UCEC	HAX1 →	+0.901	+0.280	<.001	<.001	3	6
UCEC	C1orf43 →	+0.620	+0.335	.003	<.001	3	6
OV	ARV1 →	+0.661	+0.414	.003	<.001	3	6
BRCA	TADA1 →	+0.509	+0.370	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,362 associations by consensus.

ENSA vs GOLPH3L — BRCA

Explore this scatter interactively →