ENSA

Across TCGA pan-cancer cohorts, ENSA RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ENSA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ENSA RNA is repressed in tumor relative to normal tissue. In most cancer types ENSA is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where ENSA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENSA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.217	<.001	10	view →
THCA	Male	All	−0.429	<.001	10	view →
LIHC	Female	II,III,IV	+1.199	<.001	9	view →
BRCA	All	III,IV	+0.716	<.001	6	view →
LUAD	All	All	+0.240	.003	5	view →
CHOL	All	All	+1.892	<.001	3	view →
BLCA	Male	III,IV	+0.394	.035	2	view →
KIRP	Male	All	−0.278	.011	2	view →
READ	Female	All	−0.532	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ENSA–KICH

Open the KICH breakdown →