ENPP6

Across TCGA pan-cancer cohorts, ENPP6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ENPP6 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ENPP6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ENPP6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and OV are the cancer types where ENPP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.991	0.676	<.001	52	view →
HNSC	DFS	Median	III,IV	1.000	0.814	.018	6	view →
OV	DFS	Median	All	0.845	1.000	.027	4	view →
GBM	OS	Median	All	0.255	0.523	.032	3	view →
LUAD	OS	Median	All	0.494	1.000	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ENPP6–CCRCC (OS)

Open the CCRCC breakdown →