ENPP6

Across TCGA patient cohorts, ENPP6 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP6-associated genes across cancer lineages are MEK1, Notch1, and VEGFR2. Each is linked with ENPP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP6-to-partner and partner-to-ENPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ENPP6-low versus ENPP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP6→partner) and Y-score (partner→ENPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.353	+1.700	.023	.044	3	2
UCEC	Notch1 →	+0.178	+2.222	.002	.011	3	2
SKCM	VEGFR2 →	+0.312	+3.459	.020	.005	3	1
UCEC	Rad50 →	-0.226	-2.459	.028	.019	3	1
UCEC	Tuberin →	+0.264	+1.700	.021	.044	3	1
UCEC	VHL →	-0.822	-2.115	.004	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by ENPP6 expression — UCEC

Explore this box plot interactively →