ENPP6

Across TCGA cell cohorts, ENPP6 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ENPP6-associated genes across cancer lineages are OR2L5, OR2L8, and CCDC54. Each is linked with ENPP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP6-to-partner and partner-to-ENPP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L5 grouped by ENPP6-low versus ENPP6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP6→partner) and Y-score (partner→ENPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L5 →	+0.012	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	OR2L8 →	+0.020	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	CCDC54 →	+0.146	+3.736	<.001	.004	3	1
LARGE_INTESTINE	USP17L7 →	+0.076	+3.691	<.001	.009	3	1
LARGE_INTESTINE	SPESP1 →	+1.157	+3.643	<.001	.005	3	1
LARGE_INTESTINE	PRAMEF27 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR2L5 by ENPP6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →