ENPP4

Across TCGA pan-cancer cohorts, ENPP4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ENPP4 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ENPP4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ENPP4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and BRCA are the cancer types where ENPP4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.383	0.754	<.001	49	view →
UCEC	DFS	Median	All	1.000	0.828	.009	32	view →
BRCA	OS	Median	II,III,IV	0.602	0.958	<.001	16	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
SKCM	DFS	Median	IV	0.016	0.541	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ENPP4–HNSC (OS)

Open the HNSC breakdown →