ENPP4

Across TCGA patient cohorts, ENPP4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP4-associated genes across cancer lineages are TAZ, p27_pT157, and Caspase-7-cleavedD198. Each is linked with ENPP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENPP4-to-partner and partner-to-ENPP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAZ grouped by ENPP4-low versus ENPP4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP4→partner) and Y-score (partner→ENPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TAZ →	+0.185	+1.749	.004	.049	3	2
UCEC	p27_pT157 →	-0.056	-2.768	.010	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.980	+2.662	<.001	<.001	3	2
SKCM	mTOR →	-0.320	-2.459	.001	.018	3	1
SKCM	p53 →	+0.171	+1.824	.026	.015	3	1
SKCM	p90 RSK_pT359_S363 →	+0.221	+1.807	.001	.026	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

TAZ by ENPP4 expression — SKCM

Explore this box plot interactively →