ENPP2

Across TCGA patient cohorts, ENPP2 mutation is significantly associated with the RNA expression of many other genes, with 4,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPP2-associated genes across cancer lineages are RPL12P43, MCM2, and CDRT15P8. Each is linked with ENPP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ENPP2-to-partner and partner-to-ENPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P43 grouped by ENPP2-low versus ENPP2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPP2→partner) and Y-score (partner→ENPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPL12P43 →	+0.043	+2.208	.009	.007	3	4
UCEC	MCM2 →	+0.632	+2.217	<.001	<.001	3	4
READ	CDRT15P8 →	+0.092	+4.421	<.001	.009	3	3
UCEC	MEX3D →	+0.704	+2.480	<.001	<.001	3	3
UCEC	GLRX5 →	+0.329	+1.986	.001	<.001	3	3
UCEC	DRG1 →	+0.321	+2.353	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,668 associations by consensus.

RPL12P43 by ENPP2 expression — LUSC

Explore this box plot interactively →