ENPEP

Across TCGA patient cohorts, ENPEP mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENPEP-associated genes across cancer lineages are ASNS, 14-3-3_beta, and ERK2. Each is linked with ENPEP in more than 2 cancer types. Because this analysis shows association rather than direction, both ENPEP-to-partner and partner-to-ENPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ENPEP-low versus ENPEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENPEP→partner) and Y-score (partner→ENPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.275	+1.152	.008	.048	3	3
COAD	14-3-3_beta →	-0.215	-3.144	.033	.019	3	2
UCEC	ERK2 →	+0.179	+1.485	.001	.003	3	2
UCEC	NF-kB-p65_pS536 →	-0.300	-2.807	.023	.002	3	2
UCEC	Notch1 →	+0.123	+1.115	.002	.026	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.371	-1.282	.004	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ASNS by ENPEP expression — UCEC

Explore this box plot interactively →