ENPEP

Across TCGA pan-cancer cohorts, ENPEP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ENPEP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ENPEP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ENPEP is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where ENPEP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENPEP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+2.383	<.001	11	view →
HNSC	Female	III,IV	+1.788	<.001	11	view →
KICH	All	III,IV	−3.787	<.001	10	view →
KIRP	All	II,III,IV	−1.757	.006	5	view →
READ	Male	All	+1.396	.013	4	view →
BRCA	All	All	−0.292	.002	4	view →
CHOL	All	All	−2.250	<.001	3	view →
LIHC	Female	All	−0.849	.008	3	view →
COAD	Male	II,III,IV	+0.642	<.001	3	view →
UCEC	All	All	−1.643	<.001	2	view →
LUSC	All	All	−0.577	<.001	2	view →
STAD	All	IV	+1.126	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ENPEP–KIRC

Open the KIRC breakdown →