Across TCGA pan-cancer cohorts, ENOX1-AS1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ENOX1-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where ENOX1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ENOX1-AS1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
BRCA and LUSC are the cancer types where ENOX1-AS1 tumor–normal differential expression is most reproducible.