ENO1

Across TCGA patient cohorts, ENO1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENO1-associated genes across cancer lineages are Caspase-7-cleavedD198, Chk2_pT68, and 4E-BP1. Each is linked with ENO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENO1-to-partner and partner-to-ENO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ENO1-low versus ENO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENO1→partner) and Y-score (partner→ENO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.635	+1.894	.011	.030	3	2
UCEC	Chk2_pT68 →	-0.175	-3.160	.026	.019	3	2
UCEC	4E-BP1 →	+0.366	+2.222	.001	.011	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.469	+1.700	.029	.044	3	1
UCEC	MEK1 →	+0.389	+3.584	.012	.002	3	1
UCEC	p27_pT157 →	-0.053	-3.156	.030	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Caspase-7-cleavedD198 by ENO1 expression — UCEC

Explore this box plot interactively →