ENO1

Across TCGA pan-cancer cohorts, ENO1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ENO1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ENO1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ENO1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where ENO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+1.500	<.001	12	view →
COAD	Female	II,III,IV	+1.169	<.001	12	view →
HNSC	Male	All	+1.128	<.001	12	view →
BLCA	Male	III,IV	+1.457	<.001	11	view →
LUSC	All	III,IV	+1.586	<.001	9	view →
STAD	Male	II,III,IV	+1.276	<.001	9	view →
LIHC	Male	II,III,IV	+1.205	<.001	9	view →
KIRP	All	II,III,IV	+0.846	<.001	9	view →
KICH	Female	II,III,IV	−2.288	<.001	8	view →
LUAD	Female	III,IV	+1.749	<.001	8	view →
UCEC	All	III,IV	+1.717	<.001	6	view →
READ	All	All	+0.757	.011	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ENO1–KIRC

Open the KIRC breakdown →