ENO1-AS1

Across TCGA pan-cancer cohorts, ENO1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ENO1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ENO1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ENO1-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where ENO1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENO1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.892	<.001	11	view →
THCA	Male	III,IV	−1.421	<.001	10	view →
KICH	Male	All	−1.451	<.001	8	view →
LIHC	All	III,IV	+0.507	<.001	8	view →
LUSC	All	All	+0.374	<.001	5	view →
BLCA	All	III,IV	+0.571	.019	4	view →
BRCA	All	All	−0.368	<.001	4	view →
COAD	Male	IV	−0.822	<.001	2	view →
HNSC	Female	III,IV	−0.432	.023	2	view →
PRAD	All	All	+0.430	<.001	2	view →
KIRP	All	All	−0.477	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ENO1-AS1–KIRC

Open the KIRC breakdown →