ENKUR

Across TCGA patient cohorts, ENKUR mutation is significantly associated with the RNA expression of many other genes, with 1,941 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENKUR-associated genes across cancer lineages are TRAJ57, MLLT10P2, and TRAV11. Each is linked with ENKUR in more than 1 cancer types. Because this analysis shows association rather than direction, both ENKUR-to-partner and partner-to-ENKUR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ57 grouped by ENKUR-low versus ENKUR-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENKUR→partner) and Y-score (partner→ENKUR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRAJ57 →	+0.670	+5.230	<.001	.007	3	2
UCEC	MLLT10P2 →	+0.139	+2.434	<.001	.009	3	2
UCEC	TRAV11 →	+0.195	+2.259	<.001	.007	3	2
READ	GTF3AP2 →	+0.172	+6.257	<.001	.001	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2
BRCA	MIR8062 →	+0.394	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,941 associations by consensus.

TRAJ57 by ENKUR expression — BRCA

Explore this box plot interactively →