ENKD1

Across TCGA cell cohorts, ENKD1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENKD1-associated genes across cancer lineages are DEUP1, OR10W1, and TAFA1. Each is linked with ENKD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ENKD1-to-partner and partner-to-ENKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEUP1 grouped by ENKD1-low versus ENKD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENKD1→partner) and Y-score (partner→ENKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEUP1 →	+0.305	+3.569	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+3.240	.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	ANKRD63 →	+0.279	+3.963	<.001	.001	3	1
LARGE_INTESTINE	OOSP3 →	+0.072	+3.285	.003	.007	3	1
LARGE_INTESTINE	ADAMTS4 →	+0.137	+3.555	<.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

DEUP1 by ENKD1 expression — LARGE_INTESTINE

Explore this box plot interactively →