ENHO

Across TCGA cell cohorts, ENHO mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ENHO-associated genes across cancer lineages are PPP1R2C, TMCO5A, and CCDC195. Each is linked with ENHO in more than 1 cancer types. Because this analysis shows association rather than direction, both ENHO-to-partner and partner-to-ENHO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R2C grouped by ENHO-low versus ENHO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENHO→partner) and Y-score (partner→ENHO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R2C →	+0.046	+4.095	<.001	.009	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CCDC195 →	+0.044	+4.467	.003	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.032	+4.169	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PPP1R2C by ENHO expression — LARGE_INTESTINE

Explore this box plot interactively →