ENGASE

Across TCGA patient cohorts, ENGASE mutation is significantly associated with the RNA expression of many other genes, with 1,393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENGASE-associated genes across cancer lineages are TIPIN, PFN3, and LINC00904. Each is linked with ENGASE in more than 2 cancer types. Because this analysis shows association rather than direction, both ENGASE-to-partner and partner-to-ENGASE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIPIN grouped by ENGASE-low versus ENGASE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENGASE→partner) and Y-score (partner→ENGASE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIPIN →	+0.399	+2.108	.007	.003	3	3
LUSC	PFN3 →	+0.131	+4.144	.009	.004	3	3
LIHC	LINC00904 →	+0.071	+4.720	<.001	.005	3	2
LIHC	H4C7 →	+0.091	+4.423	<.001	.007	3	2
UCEC	LINC02550 →	-0.478	-3.309	.006	.004	3	2
UCEC	TAF9 →	+0.691	+3.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,393 associations by consensus.

TIPIN by ENGASE expression — UCEC

Explore this box plot interactively →