ENG

Across TCGA patient cohorts, ENG RNA expression is significantly associated with the protein abundance of many other proteins, with 18,705 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ENG-associated proteins across cancer lineages are BGN, KANK2, and LUM. Each is linked with ENG in more than 8 cancer types. Because this analysis shows association rather than direction, both ENG-to-partner and partner-to-ENG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ENG versus BGN in GBM, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ENG→partner) and Y-score (partner→ENG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BGN →	+0.914	+0.659	<.001	<.001	3	9
UCEC	KANK2 →	+0.515	+0.476	.001	.003	3	9
GBM	LUM →	+1.297	+0.919	<.001	<.001	3	9
UCEC	PRKG1 →	+0.663	+0.734	<.001	<.001	3	9
CCRCC	STAB1 →	+0.461	+0.616	<.001	.001	3	8
PDAC	CD34 →	+0.732	+0.622	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,705 associations by consensus.

ENG vs BGN — GBM

Explore this scatter interactively →