ENG

Across TCGA pan-cancer cohorts, ENG RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ENG data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ENG RNA is associated with better overall survival. In most high-consensus cancer types, elevated ENG expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

KIRC, LIHC, and HNSC are the cancer types where ENG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.699	0.558	<.001	137	view →
LIHC	OS	Median	All	0.763	0.609	<.001	98	view →
HNSC	DFS	Quartile	III,IV	0.651	0.387	<.001	85	view →
LGG	DFS	Median	All	0.667	0.805	<.001	54	view →
MESO	OS	Tertile	All	0.217	0.673	.001	45	view →
COAD	DFS	Quartile	All	0.314	0.602	.004	25	view →
KIRP	DFS	Quartile	All	0.586	1.000	.006	25	view →
THYM	DFS	Median	All	0.967	0.684	.011	20	view →
LUSC	OS	Tertile	All	0.367	0.502	.006	19	view →
LAML	DFS	Quartile	All	0.455	0.699	.006	18	view →
LUAD	OS	Tertile	II,III,IV	0.799	0.637	.020	18	view →
STAD	OS	Tertile	All	0.346	0.584	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ENG–KIRC (OS)

Open the KIRC breakdown →