ENG

Across TCGA patient cohorts, ENG protein abundance is significantly associated with the protein abundance of many other proteins, with 37,398 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ENG-associated proteins across cancer lineages are ITGA1, ARHGEF17, and ADGRA2_S1107. Each is linked with ENG in more than 8 cancer types. Because this analysis shows association rather than direction, both ENG-to-partner and partner-to-ENG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ENG versus ITGA1 in UCEC, with a Pearson correlation of 0.42.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ENG→partner) and Y-score (partner→ENG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGA1 →	+0.589	+0.444	<.001	<.001	3	9
CCRCC	ARHGEF17 →	+0.498	+0.554	<.001	<.001	3	8
UCEC	ADGRA2_S1107 →	+0.722	+0.536	<.001	<.001	3	8
UCEC	CD248 →	+0.501	+0.514	<.001	<.001	3	8
CCRCC	CD34 →	+0.833	+0.542	<.001	<.001	3	8
UCEC	COL15A1 →	+0.577	+0.344	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 37,398 associations by consensus.

ENG vs ITGA1 — UCEC

Explore this scatter interactively →