ENG

Across TCGA cell cohorts, ENG mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ENG-associated genes across cancer lineages are PNPLA5, USP29, and TEX33. Each is linked with ENG in more than 1 cancer types. Because this analysis shows association rather than direction, both ENG-to-partner and partner-to-ENG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA5 grouped by ENG-low versus ENG-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENG→partner) and Y-score (partner→ENG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PNPLA5 →	+0.093	+3.693	<.001	.009	3	1
LARGE_INTESTINE	USP29 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TEX33 →	+0.064	+4.467	<.001	.004	3	1
BLOOD_Leukemia	C20orf85 →	+0.024	+3.969	<.001	.009	3	1
BLOOD_Leukemia	IL22 →	+0.025	+4.569	<.001	.003	3	1
BLOOD_Leukemia	ASPG →	+0.288	+3.803	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PNPLA5 by ENG expression — CNS

Explore this box plot interactively →