ENDOU

Across TCGA pan-cancer cohorts, ENDOU mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ENDOU data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ENDOU mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ENDOU expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and UCEC are the cancer types where ENDOU mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.958	0.763	<.001	27	view →
LSCC	DFS	Tertile	All	1.000	0.390	.004	12	view →
UCEC	DFS	Tertile	III,IV	0.830	0.349	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ENDOU–HNSC (OS)

Open the HNSC breakdown →