ENDOU

Across TCGA pan-cancer cohorts, ENDOU RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ENDOU’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ENDOU RNA is repressed in tumor relative to normal tissue. In most cancer types ENDOU is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where ENDOU tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENDOU RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−3.515	<.001	12	view →
KIRC	Female	III,IV	−0.348	<.001	12	view →
KICH	All	II,III,IV	−0.654	<.001	9	view →
LUAD	Female	III,IV	−0.671	<.001	8	view →
THCA	Female	All	−0.433	<.001	7	view →
BRCA	All	All	−0.507	<.001	6	view →
BLCA	All	All	−0.992	.029	5	view →
COAD	Male	II,III,IV	−0.194	<.001	4	view →
STAD	All	II,III,IV	−1.385	.039	2	view →
KIRP	All	All	−0.189	.013	2	view →
LUSC	Female	All	−0.347	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ENDOU–HNSC

Open the HNSC breakdown →