ENDOU

Across TCGA patient cohorts, ENDOU mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENDOU-associated genes across cancer lineages are eIF4E, p21, and Caspase-7-cleavedD198. Each is linked with ENDOU in more than 2 cancer types. Because this analysis shows association rather than direction, both ENDOU-to-partner and partner-to-ENDOU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ENDOU-low versus ENDOU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENDOU→partner) and Y-score (partner→ENDOU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.212	+2.169	.007	.003	3	2
UCEC	p21 →	+0.175	+2.169	.015	.003	2	3
UCEC	Caspase-7-cleavedD198 →	+0.844	+2.434	<.001	.001	3	2
UCEC	c-Met_pY1235 →	+0.058	+1.884	.036	.030	3	2
UCEC	14-3-3_beta →	-0.098	-2.432	.009	.018	3	1
UCEC	eEF2 →	+0.312	+3.321	.020	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by ENDOU expression — UCEC

Explore this box plot interactively →