ENDOG

Across TCGA pan-cancer cohorts, ENDOG RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ENDOG data layer compared with 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ENDOG RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ENDOG expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCEC show a favorable association.

KIRP, UVM, and UCEC are the cancer types where ENDOG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	1.000	0.448	<.001	74	view →
UVM	OS	Median	All	0.742	1.000	.003	67	view →
UCEC	DFS	Quartile	III,IV	0.797	0.405	.002	64	view →
UCS	DFS	Tertile	III,IV	0.198	0.591	<.001	62	view →
ACC	DFS	Median	All	0.228	0.679	<.001	60	view →
BLCA	DFS	Tertile	III,IV	0.302	0.593	.002	35	view →
COAD	DFS	Median	All	0.614	0.394	.001	21	view →
PCPG	DFS	Median	All	0.803	0.963	.001	20	view →
ESCA	DFS	Quartile	III,IV	0.299	0.601	.007	15	view →
SKCM	OS	Quartile	All	0.238	0.439	<.001	14	view →
LGG	OS	Tertile	All	0.884	0.768	.002	13	view →
THYM	OS	Median	All	1.000	0.918	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ENDOG–KIRP (DFS)

Open the KIRP breakdown →