ENDOG

Across TCGA pan-cancer cohorts, ENDOG RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ENDOG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ENDOG RNA is repressed in tumor relative to normal tissue. In most cancer types ENDOG is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, LUSC, and STAD are the cancer types where ENDOG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENDOG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.869	<.001	9	view →
LUSC	All	II,III,IV	+0.517	<.001	7	view →
STAD	All	II,III,IV	+0.614	.006	4	view →
BRCA	All	All	+0.269	.006	4	view →
LUAD	All	IV	+0.864	.013	2	view →
UCEC	All	All	+0.652	.017	2	view →
THCA	All	IV	−0.637	.010	2	view →
COAD	Female	II,III,IV	+0.468	.045	2	view →
CHOL	Male	All	−0.763	.036	1	view →
HNSC	Male	III,IV	+0.476	.026	1	view →
LIHC	Female	All	+0.419	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ENDOG–KIRC

Open the KIRC breakdown →